Red Bud fell behind 22-8 in the first quarter and it was all Cahokia the rest of the way, as the Lady Musketeers fell 63-33 Thursday night.
The Lady Musketeers trailed 39-19 at halftime, and were outscored 14-12 in the third and 10-2 in the fourth for the lopsided loss.
Tara Hubert scored 10 points to lead Red Bud, while Tori Albert and Kailey Schoenbeck each had seven.
Red Bud fell to 3-7 on the season with the loss.