Nashville rallied from a seven-point first half deficit to hand Pinckneyville its first conference loss of the season 40-38 Friday night in SIRR Mississippi Division action.
The Panthers led 12-7 at the end of the first quarter and 24-17 at the break.
Nashville fought back to outscore Pinckneyville 13-7 in the third and 10-7 in the fourth for the two-point win.
Jake Bathon led Pinckneyville with 13 points and Kyle Lamb added nine.
With the loss, Pinckneyville dropped to 19-4 overall and 5-1 in the conference.